Comparison of Endothelin Release in Bronchial Asthma, Chronic Obstructive Pulmonary Disease and Healthy Controls.
- Author:
Jung Hyun CHANG
1
Author Information
1. Department of Internal Medicine and Medical Research Center, Colledge of Medicine, Ewha Womans University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Bronchial Asthma;
COPD;
Endothelin
- MeSH:
Asthma*;
Dyspnea;
Endothelins*;
Plasma;
Pulmonary Disease, Chronic Obstructive*
- From:Korean Journal of Medicine
1998;55(1):69-74
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Both bronchial asthma and chronic obstructive pulmonary disease(COPD) are defined as disease entities causing sudden exacerbation of dyspnea; the former is a reversible airflow obstruction and the latter partially reversible and characterized by slowly progressive airflow obstruction. There were several reports suggesting endothelin release during an acute exacerbation of asthma and COPD, however few report showed comparative data of asthma and COPD concomitantly. The author examined the release of endothelin in COPD in comparison with those in asthmatics and healthy controls. METHODS: Plasma and 24 hour urine were collected from 33 asthmatics and 13 COPDs during an acute respiratory exacerbation and from 10 healthy controls. Endothelin was determined by radioimmmunoassay. RESULTS: Plasma endothelins were elevated in asthma and COPD and there were no significant changes compared with controls. Endothelin excretion in 24 hour urine was significantly higher in asthma and COPD than in controls. Endothelin concentrations in 24 hour urine showed a negative correlation with FEV1. CONCLUSION: Endothelins in 24 hour urine were increased in acute exacerbation of asthma and COPD and these increases were negatively correlated with FEV1 significantly. These findings are interpreted that endothelin contributes to the pathogenesis of acute exacerbation in asthma and COPD.
