Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms.
- Author:
Myong Ki BAEG
1
;
Myung Gyu CHOI
;
Yun Duk JUNG
;
Sun Hye KO
;
Chul Hyun LIM
;
Hyung Hun KIM
;
Jin Su KIM
;
Yu Kyung CHO
;
Jae Myung PARK
;
In Seok LEE
;
Sang Woo KIM
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Colorectal neoplasms; Esophageal neoplasms; Esophageal squamous cell carcinoma; Colonoscopy; Colorectal adenoma and carcinoma
- MeSH: Adenocarcinoma/diagnosis/*etiology; Adenoma/diagnosis/*etiology; Aged; Carcinoma, Squamous Cell/diagnosis/*etiology; Case-Control Studies; Colonoscopy; Colorectal Neoplasms/diagnosis/*etiology; Esophageal Neoplasms/diagnosis/*etiology; Female; Humans; Male; Middle Aged; Neoplasms, Multiple Primary/diagnosis/*etiology; Odds Ratio; Retrospective Studies; Risk Factors
- From:Gut and Liver 2016;10(1):76-82
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Esophageal squamous cell carcinoma (ESCC) and colorectal neoplasms (CRNs) share risk factors. We aimed to investigate whether the CRN risk is increased in ESCC patients. METHODS: ESCC patients who underwent a colonoscopy within 1 year of diagnosis were retrospectively analyzed. Patients were matched 1:3 by age, gender, and body mass index to asymptomatic controls. CRN was defined as the histological confirmation of adenoma or adenocarcinoma. Advanced CRN was defined as any of the following: > or =3 adenomas, high-grade dysplasia, villous features, tumor > or =1 cm, or adenocarcinoma. The risk factors for both CRN and advanced CRN were evaluated by univariate and multivariate analyses. RESULTS: Sixty ESCC patients were compared with 180 controls. The ESCC group had significantly higher numbers of CRNs (odds ratio [OR], 2.311; 95% confidence interval [CI], 1.265 to 4.220; p=0.006) and advanced CRNs (OR, 2.317; 95% CI, 1.185 to 4.530; p=0.013). Significant risk factors for both CRN and advanced CRN by multivariate analysis included ESCC (OR, 2.157, 95% CI, 1.106 to 4.070, p=0.024; and OR, 2.157, 95% CI, 1.045 to 4.454, p=0.038, respectively) and older age (OR, 1.068, 95% CI, 1.032 to 1.106, p<0.001; and OR, 1.065, 95% CI, 1.024 to 1.109, p=0.002, respectively). CONCLUSIONS: The rates of CRN and advanced CRN are significantly increased in ESCC. Colonos-copy should be considered at ESCC diagnosis.
