Role and mechanism of platelet-derived growth factor BB in repair of growth plate injury
- VernacularTitle:血小板衍生生长因子BB参与生长板损伤修复的作用与机制
- Author:
Hongcheng PENG
1
,
2
;
Guoxuan PENG
;
Anyi LEI
;
Yuan LIN
;
Hong SUN
;
Xu NING
;
Xianwen SHANG
;
Jin DENG
;
Mingzhi HUANG
Author Information
- Keywords: growth plate injury; bone bridge; platelet-derived growth factor BB; cartilage regeneration; review
- From: Chinese Journal of Tissue Engineering Research 2025;29(7):1497-1503
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:In the initial stage of growth plate injury inflammation,platelet-derived growth factor BB promotes the repair of growth plate injury by promoting mesenchymal progenitor cell infiltration,chondrogenesis,osteogenic response,and regulating bone remodeling. OBJECTIVE:To elucidate the action mechanism of platelet-derived growth factor BB after growth plate injury. METHODS:PubMed,VIP,WanFang,and CNKI databases were used as the literature sources.The search terms were"growth plate injury,bone bridge,platelet-derived growth factor BB,repair"in English and Chinese.Finally,66 articles were screened for this review. RESULTS AND CONCLUSION:Growth plate injury experienced early inflammation,vascular reconstruction,fibroossification,structural remodeling and other pathological processes,accompanied by the crosstalk of chondrocytes,vascular endothelial cells,stem cells,osteoblasts,osteoclasts and other cells.Platelet-derived growth factor BB,as an important factor in the early inflammatory response of injury,regulates the injury repair process by mediating a variety of cellular inflammatory responses.Targeting the inflammatory stimulation mediated by platelet-derived growth factor BB may delay the bone bridge formation process by improving the functional activities of osteoclasts,osteoblasts,and chondrocytes,so as to achieve the injury repair of growth plate.Platelet-derived growth factor BB plays an important role in angiogenesis and bone repair tissue formation at the injured site of growth plate and intrachondral bone lengthening function of uninjured growth plate.Inhibition of the coupling effect between angiogenesis initiated by platelet-derived growth factor BB and intrachondral bone formation may achieve the repair of growth plate injury.
