Pathogenesis and treatment progress of flap ischemia-reperfusion injury
10.12307/2025.298
- VernacularTitle:皮瓣缺血再灌注损伤的发病机制及治疗进展
- Author:
Bo HE
1
;
Wen CHEN
;
Suilu MA
;
Zhijun HE
;
Yuan SONG
;
Jinpeng LI
;
Tao LIU
;
Xiaotao WEI
;
Weiwei WANG
;
Jing XIE
Author Information
1. 南阳市中医院,河南省 南阳市 473007
- Keywords:
flap;
ischemia-reperfusion injury;
inflammatory response;
oxidative stress;
Ca2+overload;
apoptosis;
mesenchymal stem cell;
platelet-rich plasma;
signaling pathway;
shock wave;
pretreatment
- From:
Chinese Journal of Tissue Engineering Research
2025;29(6):1230-1238
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Flap transplantation technique is a commonly used surgical procedure for the treatment of severe tissue defects,but postoperative flap necrosis is easily triggered by ischemia-reperfusion injury.Therefore,it is still an important research topic to improve the survival rate of transplanted flaps. OBJECTIVE:To review the pathogenesis and latest treatment progress of flap ischemia-reperfusion injury. METHODS:CNKI,WanFang Database and PubMed database were searched for relevant literature published from 2014 to 2024.The search terms used were"flap,ischemia-reperfusion injury,inflammatory response,oxidative stress,Ca2+overload,apoptosis,mesenchymal stem cells,platelet-rich plasma,signaling pathways,shock wave,pretreatment"in Chinese and English.After elimination of irrelevant literature,poor quality and obsolete literature,77 documents were finally included for review. RESULTS AND CONCLUSION:Flap ischemia/reperfusion injury may be related to pathological factors such as inflammatory response,oxidative stress response,Ca2+overload,and apoptosis,which can cause apoptosis of vascular endothelial cells,vascular damage and microcirculation disorders in the flap,and eventually lead to flap necrosis.Studies have found that mesenchymal stem cell transplantation,platelet-rich plasma,signaling pathway modulators,shock waves,and pretreatment can alleviate flap ischemia/reperfusion injuries from different aspects and to varying degrees,and reduce the necrosis rate and necrosis area of the grafted flap.Although there are many therapeutic methods for skin flap ischemia/reperfusion injury,a unified and effective therapeutic method has not yet been developed in the clinic,and the advantages and disadvantages of various therapeutic methods have not yet been compared.Most of the studies remain in the stage of animal experiments,rarely involving clinical observations.Therefore,a lot of research is required in the future to gradually move from animal experiments to the clinic in order to better serve the clinic.
