The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance.
- Author:
Mee Sup YOON
1
;
Cheol Soo CHOI
Author Information
- Publication Type:Review
- MeSH: Amino Acids; Insulin Resistance*; Insulin*; Intercellular Signaling Peptides and Proteins; Lysosomes; Metabolism; Sirolimus*
- From:Experimental & Molecular Medicine 2016;48(1):e201-
- CountryRepublic of Korea
- Language:English
- Abstract: Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.
