Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair
10.3760/cma.j.cn501225-20220912-00402
- VernacularTitle:提高间充质干细胞外泌体创面修复疗效的研究进展
- Author:
Yuren DUAN
1
;
Yuchen ZHAO
;
Wenyu SONG
;
Jiaxin WANG
;
Jie PEI
;
Xiaobing WANG
Author Information
1. 山西医科大学第一医院烧伤整形科，太原 030001
- Keywords:
Mesenchymal stem cells;
Exosomes;
Hydrogel;
Wound repair
- From:
Chinese Journal of Burns
2023;39(7):695-700
- CountryChina
- Language:Chinese
-
Abstract:
How to promote high-quality wound healing is a common problem for plastic surgery and burn physicians. In recent years, numerous animal studies have demonstrated that mesenchymal stem cell-derived exosomes promote wound repair through multiple mechanisms and are promising cell-free therapeutic agents with broad prospect of application. How to enhance the therapeutic efficacy of exosomes, optimize their drug delivery strategy, and improve their biological properties are the challenges to be overcome in order to move from basic research to clinical application of exosome therapy for wound repair. This article focuses on methods to improve the wound repair potential of mesenchymal stem cell-derived exosomes, and reviews the recent research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair from three aspects, including pretreatment of parental mesenchymal stem cells, hydrogel bio-scaffold loaded with exosomes, and engineered exosomes, to provide a reference for further clinical studies.
