Research advances on the role of complement system activation in post-burn immunity
10.3760/cma.j.cn501225-20220726-00313
- VernacularTitle:补体系统激活在烧伤后免疫中的作用研究进展
- Author:
Shengyu HUANG
1
;
Feng ZHU
;
Guanghua GUO
Author Information
1. 南昌大学第一附属医院烧伤整形与创面修复医学中心，南昌 330006
- Keywords:
Burns;
Complement activation;
Immunity;
Coagulation cascade
- From:
Chinese Journal of Burns
2023;39(4):396-400
- CountryChina
- Language:Chinese
-
Abstract:
Immune activation is one of the major factors of secondary injury post burn, and is the main organismal response in the anti-infection process. As an important part of the innate immune response, the complement system is able to induce the activation of immune cells after burns, promote inflammation and mediate the breakdown of the immune barrier, and even engage in complex cross-linking with the coagulation cascade. This article reviews the role of complement system activation in post-burn immunity and its possibility of clinical translation from the perspectives of innate immunity, acquired immunity, and cross-linking of the complement system with the coagulation cascade.
