Research progress on the role of adipose-derived stem cell exosomes in skin scar formation
10.3760/cma.j.cn501225-20220308-00057
- VernacularTitle:脂肪干细胞外泌体在皮肤瘢痕形成中的作用研究进展
- Author:
Liuxin WANG
1
;
Yunpeng LI
;
Simo WU
;
Junrui ZHANG
;
Liang KONG
;
Bin LU
;
Fuwei LIU
;
Zhiye LI
Author Information
1. 空军军医大学基础医学院，西安 710032
- Keywords:
Exosomes;
Cicatrix;
Fibroblasts;
Extracellular matrix;
Adipose-derived stem cells
- From:
Chinese Journal of Burns
2023;39(3):295-300
- CountryChina
- Language:Chinese
-
Abstract:
The adipose-derived stem cell exosomes are subcellular structures of adipose stem cells. They are nano-sized membrane vesicles that can transport various cell components and act on target cells by paracrine, and they play an important role in the exchanges of substance and information between cells. Scar healing is the commonest way of healing after skin tissue injury. Pathological scar can not only cause movement dysfunction, but also lead to deformity, which affects the appearance of patients and brings life and mental pressure to the patients. In recent years, many researches have shown that the adipose-derived stem cell exosomes contain a variety of bioactive molecules, which play an important role in reducing scar formation and scar-free wound healing, by affecting the proliferation and migration of fibroblasts and the composition of extracellular matrix. This article reviewed the recent literature on the roles and mechanisms of adipose-derived stem cell exosomes in scar formation, and prospected the future application and development of adipose-derived stem cell exosomes in scar treatment.
