Progress on the mechanism and application of adipose-derived stem cells in promoting wound repair

VernacularTitle:脂肪干细胞促进创面修复的机制与应用进展
Author: Tianyi SUN ¹ ; Feng LU ; Jianhua GAO ; Cheng ZHOU ; Ziqing DONG ; Bin LI
Author Information

1. 南方医科大学南方医院整形美容外科，广州　510515
Keywords: Mesenchymal stem cells; Neovascularization, physiologic; Stem cell transplantation; Adipose-derived stem cell; Chronic wound; Wound repair
From: Chinese Journal of Burns 2022;38(12):1190-1195
CountryChina
Language:Chinese
Abstract: Chronic refractory wounds and scars caused by abnormal wound repair seriously damage the health of patients and affect their quality of life. At present, there is a lack of simple but effective and economical treatment methods. Adipose-derived stem cells (ASCs), as a kind of mesenchymal stem cells with multi-directional differentiation potential, have been confirmed by several in vivo and in vitro studies to promote wound healing by promoting epithelialization, angiogenesis, immunoregulation, antioxidant properties, and other mechanisms. ASCs and their derivatives have been used in the treatment of refractory wounds caused by burns, diabetic, and radiation injuries with good results achieved. Their potential to become new materials for wound repair has also been confirmed. This paper reviewed the mechanism and clinical application of ASCs in promoting wound repair, and looked into its research direction and prospects.