Research advances on pharmacological interventions for hypertrophic scar
10.3760/cma.j.cn501120-20211118-00388
- VernacularTitle:药物干预增生性瘢痕的研究进展
- Author:
Liangliang SHI
1
;
Mingzhuo LIU
;
Zhengying JIANG
;
Xiaoting YU
;
Jiaqi LI
;
Guanghua GUO
Author Information
1. 南昌大学第一附属医院烧伤整形与创面修复医学中心，南昌 330006
- Keywords:
Cicatrix;
Drug therapy;
Metformin;
Botulinum toxins, type A;
Exosomes
- From:
Chinese Journal of Burns
2022;38(12):1179-1184
- CountryChina
- Language:Chinese
-
Abstract:
Hypertrophic scar is an abnormal fibrous proliferative disease that occurs after deep cutaneous injury, which not only affects aesthetics and function but also has negative psychological effects on the patients. However, the mechanism of hypertrophic scar formation has not been fully elucidated, and its clinical treatment is complex with a high rate of recurrence and no radicle cure. Intervention based on molecular targets will likely be the future direction for the prevention and treatment of hypertrophic scar. In this article, we review the specific roles and mechanisms of drug-targeted interventions in hypertrophic scar formation, including general drugs, cytokines, immunomodulators, herbal extracts, exosomes, and nanomaterials, in the context of advances in both basic and clinical research at home and abroad.
