Research advances on the prevention and treatment strategies of burn wound progressive deepening
10.3760/cma.j.cn501120-20200828-00396
- VernacularTitle:烧伤创面进行性加深防治策略研究进展
- Author:
Haisheng LI
1
;
Gaoxing LUO
;
Zhiqiang YUAN
Author Information
1. 陆军军医大学（第三军医大学）第一附属医院全军烧伤研究所，创伤、烧伤与复合伤 国家重点实验室，重庆 400038
- Keywords:
Burns;
Wound progressive deepening;
Treatment and prevention
- From:
Chinese Journal of Burns
2021;37(12):1199-1204
- CountryChina
- Language:Chinese
-
Abstract:
The progressive deepening of burn wounds is one of the common clinical problems and difficulties in early burn treatment. At the present, it is believed that local ischemia and hypoxia, persistent inflammation, infection, unbalanced local microenvironment, cell necrosis, apoptosis, and autophagy are the main mechanisms of progressive deepening of burn wounds. In recent years, basic and clinical studies have proposed various new strategies for prevention and treatment of progressive deepening of burn wounds, mainly including correct cooling, improving blood perfusion of the wound, early debridement, improving the wound microenvironment, preventing and treating wound infection, reducing wound inflammation, and inhibiting the oxidative stress in the wound. This review focuses on the current progress of prevention and treatment strategies of burn wound progressive deepening, in order to provide references for the treatment of burn wounds.
