Research advances on the cholinergic inflammatory reflex and inflammation resolution
10.3760/cma.j.cn501120-20200609-00299
- VernacularTitle:胆碱能炎症反射与炎症消退研究进展
- Author:
Zhuo CHEN
1
;
Xiao HE
;
Mengwei YAO
;
Zhan LI
;
Xiang XU
Author Information
1. 陆军军医大学（第三军医大学）基础医学院，重庆 400038
- Keywords:
Inflammation;
Vagus nerve;
Cholinergic inflammation reflex;
Inflammation resolution;
Specialized pro-resolving mediators
- From:
Chinese Journal of Burns
2021;37(9):885-889
- CountryChina
- Language:Chinese
-
Abstract:
The vagus nerve plays an important role in regulating the homeostasis of inflammation. Inflammation signals in the body are passed to the vagus nerve efferent fibers via nerve reflexes, and the signals generated by efferent fibers will play an anti-inflammatory role in various inflammatory diseases through immune cells such as T cells that express choline acetyltransferase and macrophages. However, the resolution of inflammation is not only the interaction between pro-inflammatory and anti-inflammatory cytokines, but also an active process of biosynthesis, including the synthesis of various pro-resolving mediators and their physiological utility process. Moreover, the cholinergic inflammation reflex also plays a crucial role in inflammation resolution. This review reviews and summarizes the cholinergic inflammatory reflex and its key role in the process of inflammation resolution.
