Research advances on the regulation of interleukin-17 signal transduction and the implication of interleukin-17 in sepsis
10.3760/cma.j.cn501120-20200515-00266
- VernacularTitle:白细胞介素17的信号转导调控及白细胞介素17在脓毒症中作用的研究进展
- Author:
Yanhui JIA
1
;
Jiaqi LIU
;
Yunchuan WANG
;
Hongtao WANG
;
Ke TAO
;
Zhao ZHENG
;
Dahai HU
Author Information
1. 空军军医大学第一附属医院全军烧伤中心，烧伤与皮肤外科，西安 710032
- Keywords:
Interleukin-17;
Sepsis;
Signal transduction;
Transcription factors
- From:
Chinese Journal of Burns
2021;37(7):675-680
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis remains a leading cause of death in critical patients. Both excessive inflammatory response and long-term immunosuppression can lead to the death of sepsis patients. As a key pro-inflammatory cytokine, interleukin-17 (IL-17) plays an important role in the body's inflammatory response and immune system. The signal transduction of IL-17 is a key link in maintaining the body's health and participating in the onset and development of sepsis. This review mainly summarizes and discusses the regulation of IL-17 signal transduction and pathogenic and protective role of IL-17 in sepsis.
