Esophageal acid clearance in patients with ineffective esophageal motility.
- Author:
Gwang Ha KIM
1
;
Yong Mock BAE
;
Eul Jo JEONG
;
Jae Hyeon MOON
;
Jin Kwang AN
;
Jin Seon KIM
;
Jeong HEO
;
Dae Hwan KANG
;
Geun Am SONG
;
Mong CHO
;
Ung Suk YANG
Author Information
1. Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea. doc0224@chollian.net
- Publication Type:Original Article
- Keywords:
Ineffective esophageal motility;
Esophageal acid clearance
- MeSH:
Esophageal Motility Disorders;
Esophageal pH Monitoring;
Esophageal Sphincter, Lower;
Esophagus;
Gastroesophageal Reflux;
Humans;
Manometry;
Peristalsis;
United Nations
- From:Korean Journal of Medicine
2002;63(4):386-393
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Failed or hypotensive peristalsis, two of the diagnostic criteria for NEMD, correlates with impaired anterograde propulsion and retrograde escape of esophageal contents. The aim of this study was to evaluate esophageal acid clearance (EAC) in patients with ineffective esophageal motility (IEM). METHODS: Of 252 patients performing esophageal manometry and ambulatory esophageal pH monitoring, 51 patients with normal motility and acid reflux and 40 patients with IEM and acid reflux were included. RESULTS: The amplitude of peristaltic waves in the proximal and distal esophagus and lower esophageal sphincter pressure was lower significantly in patients with IEM than those with normal motility. Percentage of time of pH<4 in total, upright, and supine period and number of reflux episodes was not different in both. Supine EAC was significantly increased in patients with IEM when compared to those with normal motility. Upright EAC was not different in both. CONCLUSION: We concluded supine EAC is increased in patients with IEM. Since IEM is frequently associated with gastroesophageal reflux disease (GERD), a more intensive therapy must be needed. We propose IEM can be as a specific entity of primary esophageal motility disorder, especially in patients with GERD.
