New understanding on the immunity for severe infections and complications in burns and trauma
10.3760/cma.j.cn501120-20210118-00025
- VernacularTitle:严重烧创伤感染及其并发症的免疫新认识
- Author:
Yongming YAO
1
;
Yingyi LUAN
Author Information
1. 解放军总医院第四医学中心、医学创新研究部转化医学研究中心，北京 100048
- Keywords:
Burns;
Infection;
Immunomodulation;
Therapeutic uses;
Complication
- From:
Chinese Journal of Burns
2021;37(6):519-523
- CountryChina
- Language:Chinese
-
Abstract:
The mechanisms of burn/trauma related infection are complicated, involving uncontrolled inflammation, immune disorder, coagulation abnormality, and pathophysiological changes of multiple systems or organs. Although active management of primary diseases, application of antibiotics, and organ support treatment are the basis for the management of burn/trauma related infection, immune modulation opens up a new direction for the intervention of burn/trauma related infection and the relevant complications. In-depth understanding of inflammation-immune response and its regulatory mechanisms, and exploring new early warning biomarkers and immune interventional strategies are of great significance for improving the level of treatment of clinical burn/trauma related infections and improving the prognosis of patients.
