Study on the effect of carboxymethyl-chitosan in the prevention of postoperative abdominal adhesion and its mechanism of action
- VernacularTitle:羧甲基壳聚糖防粘连粉雾剂的应用及作用机制的研究
- Author:
Xin HONG
1
;
Bo-Yong SHEN
;
Bao-San HAN
Author Information
1. 上海交通大学医学院附属瑞金医院
- Keywords:
Abdominal adhesion;
Carboxymethyl-chitosan;
Prevention of adhesion;
Microscopy
- From:
Journal of Surgery Concepts & Practice
2009;14(4):426-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of carboxymethyl-chitosan in the prevention of postoperative abdominal adhesion and its possible mechanism of action. Methods Sixty SD rats were randomly divided into 3 groups: control group 1 (open & close model) n=20, control group 2 (intestinal adhesion model) n=20 and experimental group (use of carboxymethyl-chitosan model) n=20. The degree and incidence of adhesion by the 7th day and 14th day after operation were compared respectively. The pathologic reaction of the peritoneum was observed under microscope. Results Conceming the incidence and the degree of adhesion. the control group 2 was higher than the others; in contrast the control groupl manifested the lowest degree. Conclusion Carboxymethyl-chitosan can significantly reduce the degree of postoperative adhesion in the abdomen.
