Experimental study on the pharmacokinetics of floxuridine postoperative chemotherapy via the celiac axis
- VernacularTitle:模拟胃癌根治术后经腹腔动脉灌注FUDR的药动学研究
- Author:
Peng WU
1
;
Zheng-Gang ZHU
;
Zheng-Bao YE
;
Hong-Zhuan CHEN
;
Min YAN
;
Yan-Zhen LIN
Author Information
1. 上海市虹口区新港路街道社区卫生服务中心
- Keywords:
Gastric cancer;
Intra-arterial chemotherapy;
Pharmacokinetics
- From:
Journal of Surgery Concepts & Practice
2009;14(4):421-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacokinetics of floxuridine (FUDR) when administered postoperatively via the celiac axis in experimental animals. Methods Ten healthy prepubertal pigs underwent first radical gastrectomy, then were randomly divided into two groups (each n=5): the one group in which the drug was given via the celiac artery (CAI). and the other in which the drug was administered systemically through a vein (SC). High performance liquid chromatography (HPLC) was applied to determine the concentration of FUDR in the peripheral blood, tissues surrounding the gastric anastomosis, stomach-neighboring organs and tissues as well as in the related lymph nodes. Results The AUC0-49 and Cmax of FUDR in the tissues neigboring the gastric anastomosis in the liver, pancreas colic mesentery and the Cmax of FUDR in the lymph nodes along the celiac artery and the middle colic vessels, were significantly higher in the CAI group compared with the SC group. There were no significant difference in terms of the Cmax of FUDR in the heart and kidney between the 2 groups. Conclusions A higher concentration of FUDR in the tissues surrounding the gastric anastomosis and in the other neighboring organs and tissues can be achieved in the CAl group, indicating that a better outcome in the treatment and prevention of metastases and recurrence can be obtained through the use of CAI than the SC and without additional toxic reaction.
