Expression of Syk in different breast lesions and their clinical significance
- VernacularTitle:Syk在不同乳腺病变组织中的表达及临床意义
- Author:
Peng ZHAO
1
;
Hong-Ying WANG
;
Qiang ZOU
;
Feng TANG
;
Jian ZHOU
;
Yi-Ting JIN
;
Zheng-Yin LAO
Author Information
1. 复旦大学上海医学院附属华山医院
- Keywords:
Spleen tyrosine kinase (Syk);
Breast cancer;
Pte-cancer lesion;
Fibrocystic disease of the breast;
Immunohistochemistry
- From:
Journal of Surgery Concepts & Practice
2009;14(4):403-406
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the difference in Syk expression in different breast lesions, and to study the correlation of expression of Syk in breast cancer with other clinicopathologic markers. Methods Immunohistochemistry was used to detect Syk protein expression in cases of different breast lesions, consisting of 20 cases of fibrocystic disease of the breast 16 cases of ductal intraepithelial neoplasia 2 (DIN2) and 168 cases of breast cancer and 95 specimens of peri-cancer tissue obtained at a distance of 5 cm from the cancer tissue. Concomittantly, ER, PR, p53, HER2/neu were detected in 168 breast cancer tissue with immunohistochemical staining. Results The positive rates of Syk expression were 90.00% (18/20), 50.00%(8/16), 34.52%(58/168) and 78.95%(75/95) respectively in fibrocystic breast disease tissue, DIN2 tissue, breast cancer tissue and peri-cancer tissue. The positive expression rates of Syk were significantly lower in the breast cancer tissue than those in the fibrocystic breast disease tissue (P<0.05) and the peri-cancer tissue (P<0.05); and significantly lower in the DIN2 tissue than those in the fibrocystic breast disease tissue (P<0.05) and the peri-cancer tissue (P<0.05). The correlation between reduction of Syk expression in breast cancer tissue and the other clinicopathologic factors or prognostic markers was not found in our study. Conclusions The positive rates of Syk expression progressively decrease from the fibrocystic disease tissue, peri-cancer tissue, pre-cancer lesion to the cancerous tissue in the breast.
