Advances in Research on Small Intestinal Bacterial Overgrowth and Metabolic Dysfunction-associated Steatotic Liver Disease
10.3969/j.issn.1008-7125.2024.02.007
- VernacularTitle:小肠细菌过度生长和代谢功能障碍相关脂肪变性肝病的研究进展
- Author:
Jiali HUANG
1
;
Ziteng WANG
;
Wentao TAN
;
Pengfei ZHANG
;
Hong LIU
Author Information
1. 首都医科大学附属北京世纪坛医院消化内科(100038)
- Keywords:
Metabolic Dysfunction-Associated Steatotic Liver Disease;
Small Intestinal Bacterial Overgrowth;
Lipopolysaccharides;
Short-Chain Fatty Acids;
Bile Acids;
Choline
- From:
Chinese Journal of Gastroenterology
2024;29(2):109-113
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement of living standard and dietary changes,metabolic dysfunction-associated steatotic liver disease(MASLD)has become one of the most common chronic liver diseases worldwide.Studies have shown that alterations in gut microflora are associated with the metabolic syndrome,and MASLD is regarded as a manifestation of metabolic syndrome in the liver.In recent years,it has been found that small intestinal bacterial overgrowth(SIBO)is closely related to the development of MASLD.SIBO can contribute to MASLD by disrupting the intestinal mucosal barrier through the gut-hepatic axis,and by altering the intestinal microbiota and its metabolic products.This article reviewed the advances in research on SIBO and MASLD.
