Progress in Pathogenesis of Nervous System Injury in Gastrointestinal Motility Disorders Caused by Anti-Hu Antibody
10.3969/j.issn.1008-7125.2024.02.006
- VernacularTitle:抗Hu抗体对胃肠动力障碍性疾病神经系统损伤机制的研究进展
- Author:
Mingyu FU
1
;
Xiucai FANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院消化内科(100730)
- Keywords:
Anti-Hu Antibody;
Nervous System Injuries;
Gastrointestinal Motility Disorders;
Paraneoplastic Syndromes,Nervous System;
Intestinal Pseudo-Obstruction;
Irritable Bowel Syndrome
- From:
Chinese Journal of Gastroenterology
2024;29(2):104-108
- CountryChina
- Language:Chinese
-
Abstract:
More and more studies suggest that targeting neuronal antibodies,particularly anti-Hu antibody,can cause various degrees of damage to central nervous system and/or enteric nervous system and affect the occurrence,progression,and prognosis of related diseases.Therefore,elucidating the mechanisms of anti-Hu antibody-induced nervous system injury and its relevance to diseases is of significant importance for individualized diagnosis and treatment.This article reviewed the associations between anti-Hu antibody and paraneoplastic gastrointestinal dysmotility,chronic intestinal pseudo-obstruction,and irritable bowel syndrome,as well as the mechanisms of neuronal damage caused by anti-Hu antibody.
