Research advances on immunological properties and gene regulation of skin keratinocytes
10.3760/cma.j.cn501120-20200106-00007
- VernacularTitle:皮肤角质形成细胞的免疫学特性与基因调控研究进展
- Author:
Kun ZHANG
1
;
Chuan′an SHEN
Author Information
1. 解放军总医院第四医学中心烧伤整形科，北京 100048
- Keywords:
Wound healing;
Skin immunity;
Keratinocytes;
Immunogenicity;
Gene regulation
- From:
Chinese Journal of Burns
2021;37(1):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Keratinocytes (KCs) are the main cells that constitute the epidermis, which have immunogenicity and play important roles in immunity. KCs-mediated immune response plays an initiating role in the innate immune response. KCs recognize antigens mainly through Toll-like receptors and nucleotide-binding oligomerization domain-like receptors. After being activated, KCs up-regulate the expressions of cytokines, chemokines, and antibacterial peptides via signal transduction pathways and help initiate skin immune response. KCs also participate in early innate immune response by attracting inflammatory cells and innate immune cells such as mast cells and macrophages. Studies on the molecular biological mechanism and regulatory measures of KCs′ immunogenicity are of great significance for the construction of skin substitutes such as cell sheets to repair wounds. This article reviews the research advances in immunological properties and gene regulation of KCs.
