Research advances on the characteristics and wound healing promoting effect of in-situ forming injectable hydrogels
10.3760/cma.j.cn501120-20200428-00243
- VernacularTitle:原位成形可注射水凝胶特性及其促创面愈合作用研究进展
- Author:
Zixuan ZHOU
1
;
Yaonan JIANG
;
Shichu XIAO
Author Information
1. 海军军医大学第一附属医院烧伤外科，全军烧伤研究所，中国医学科学院烧伤暨烧创复合伤救治关键技术创新单元，上海 200433
- Keywords:
Hydrogels;
Wound healing;
Skin, artificial;
In-situ forming
- From:
Chinese Journal of Burns
2021;37(1):82-85
- CountryChina
- Language:Chinese
-
Abstract:
Research of in-situ induced repair and regeneration is a multi- and inter-disciplinary field, which is of important potentials in the treatment of both large-area deep burns and chronic wounds such as diabetic skin ulcers. In-situ forming injectable hydrogels which are hydrogel-like biomaterials that can spontaneously gelatinize in physiological condition when applied in local wounds have been explored in recent years. This kind of biomaterials contain extracellular matrix, in which cells promoting wound repairing can be added if required, and can work as release-controlled carriers for active peptides such as growth factors to simulate local wound microenvironment and induce the repair and regeneration. Herein, characteristics and function of promoting wound repair and regeneration about in-situ forming injectable hydrogels were reviewed, including material types and their relevant working mechanisms, advantages, existing problems, etc.
