Advances in the Study of the Signal Transducer and Activator of Transcriptions Family and Hearing Loss
10.3969/j.issn.1006-7299.2024.06.016
- VernacularTitle:信号传导及转录激活蛋白家族与听力损失的研究进展
- Author:
Silong WANG
1
;
Ke WU
;
Yinuo SUN
;
Meixu JIANG
;
Haiyan YIN
;
Yan GUO
Author Information
1. 济宁医学院基础医学院(济宁 272067)
- Keywords:
Signal transducer and activator of transcriptions;
Hearing loss;
Oxidative stress;
Inflam-mation;
Apoptosis
- From:
Journal of Audiology and Speech Pathology
2024;32(6):549-553
- CountryChina
- Language:Chinese
-
Abstract:
Hearing loss is one of the most common neurosensory disorders in humans,severely affecting pa-tients'quality of life with lack of ideal treatments.Its pathogenesis is related to oxidative stress,inflammation and apoptosis in the inner ear.Recent studies have demonstrated that members of the signal transducer and activator of transcriptions(STATs)family are involved in regulating gene expression in auditory cells during inner ear develop-ment and physiological activities such as apoptosis,oxidative stress,inflammation and autophagy during auditory disorders.In this paper,we review the research on STATs in inner ear development and hearing loss,and elucidate their specific molecular mechanisms,aiming to provide theoretical guidance and direction for the prevention and treatment of hearing loss.
