The Analysis of Influencing Factors of Progressive Hearing Loss in Children with Large Vestibular Aqueduct Syndrome
10.3969/j.issn.1006-7299.2024.06.005
- VernacularTitle:大前庭水管综合征患儿听力损失进展影响因素分析
- Author:
Lin DENG
1
;
Xiaohua CHENG
;
Lihui HUANG
;
Hui LIU
;
Dongxin LIU
;
Cheng WEN
;
Yue LI
;
Xiaozhe YANG
;
Junfang XIAN
Author Information
1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京市耳鼻咽喉科研究所,耳鼻咽喉头颈科学教育部重点实验室(首都医科大学)(北京 100005)
- Keywords:
Large vestibular aqueduct syndrome;
Progressive hearing loss;
Children;
Cox regression a-nalysis
- From:
Journal of Audiology and Speech Pathology
2024;32(6):500-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prognostic factors of progressive hearing loss among children with large vestibular aqueduct syndrome(LVAS).Methods The clinical data of 49 children(95 ears)with LVAS who re-ceived at least two hearing tests from January 2017 to January 2023 in our hospital were retrospectively analyzed,and they were divided into two groups according to the progression of hearing loss:the stable group(55 ears)and the progressive group(40 ears).The effects for progressive hearing loss of initial age,gender,laterality,imaging features,audiometric data,and incomplete partition type Ⅱ(IP-Ⅱ)and SLC26A4(type A,B,C,D)genotypes were analyzed by univariate and multivariate Cox regression analysis.The potential prognostic factors were further verified by Kaplan-Meier survival analysis.Results Each dB decrease in the initial average hearing threshold in-creased the expected hazard by 7.03％(P=0.02).Incomplete partition type Ⅱ(IP-Ⅱ)was associated with 5.11 hazard ratio(95％CI,1.81 to 14.45,P=0.002).Genotype C was associated with 6.13 hazard ratio for progressive hearing loss(95％CI,2.07 to 18.13,P=0.001).Conclusion The initial average hearing threshold,IP-Ⅱ,and SLC26A4 genotype C were significant effect factors of progressive hearing loss in patients with LVAS.This could predict the progression of hearing loss in children with LVAS and help identify patients at high risk for progressive hearing loss.
