Research Progress on the Role of HCN Channels in Auditory Pathway
10.3969/j.issn.1006-7299.2024.04.016
- VernacularTitle:HCN通道在听觉传导通路中的作用研究进展
- Author:
Xinying GE
1
;
Mo ZHOU
;
Jinfeng LIU
;
Jinsheng DAI
;
Jingjing YUAN
;
Mengting LIU
;
Juan ZHANG
;
Ningyu WANG
Author Information
1. 首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科(北京 100020)
- Keywords:
Hyperpolarization-activated cyclic nucleotide-gated(HCN)channel;
Hyperpolarization-activa-ted current(Ih);
Auditory conduction;
Unilateral auditory deprivation;
Sound localization
- From:
Journal of Audiology and Speech Pathology
2024;32(4):364-368
- CountryChina
- Language:Chinese
-
Abstract:
Hyperpolarization-activated cyclic nucleotide-gated(HCN)channels are widely expressed in the central and peripheral nervous systems.They can generate hyperpolarization-activated current(Ih)that regulates the resting membrane potential and excitability of neurons.Furthermore,it can affect the precise processing and con-duction of hearing,which plays a crucial role in the accurate analysis of temporal information.Therefore,through the review of HCN channel structure and distribution,as well as electrophysiological effects,the role and mecha-nism of HCN channels in the auditory pathways of the normal and unilateral or bilateral deafness patients will be fur-ther investigated.
