Research advances on the molecular mechanisms of vascular permeability in sepsis
10.3760/cma.j.cn501120-20190724-00308
- VernacularTitle:脓毒症血管通透性分子调控机制研究进展
- Author:
Xingfeng HE
1
;
Guosheng WU
;
Pengfei LUO
;
Yu SUN
;
Shengjun SHI
;
Zhaofan XIA
Author Information
1. 南方医科大学附属珠江医院烧伤整形科，广州 510515
- Keywords:
Sepsis;
Capillary permeability;
Molecular biology
- From:
Chinese Journal of Burns
2020;36(10):982-986
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is one of the critical illnesses caused by burns, trauma, shock, infection, and so on. In patients with sepsis, vascular permeability is prone to develop through various pathophysiological mechanisms and thus could result in accumulation of tissue fluid, insufficient intravascular fluid, and finally cause septic shock and multiple organ dysfunction syndrome. Recent studies have shown that various factors and mediators involved in the regulation of vascular permeability in sepsis are expected to become targets for clinical treatment of sepsis. In this paper, we have reviewed the research advances on some molecules which are significantly associated with vascular permeability in sepsis, such as vascular endothelial growth factor, angiopoietin, sphingosine-1-phosphate, heparin-binding protein, and Slit2.
