Treatment of Phentolamine combined with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for phlebitis caused by amiodarone extravasation: an animal study
10.3760/cma.j.issn.1674-2907.2018.17.011
- VernacularTitle:酚妥拉明加林可霉素利多卡因凝胶处理胺碘酮输注外渗致静脉炎的动物实验研究
- Author:
Huiren ZHUANG
1
;
Youqing PENG
Author Information
1. 200120,上海市东方医院普外科
- Keywords:
Phentolamine;
Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel;
Infusion extravasation;
Amiodarone
- From:
Chinese Journal of Modern Nursing
2018;24(17):2036-2039
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of Phentolamine combined with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for phlebitis caused by amiodarone extravasation in an animal study.Methods A total of 15 adult rabbits were selected in March 2017. We built a model according to amiodarone damage. All of the rabbits were numbered by weight from light to heavy and divided into five groups with the random number table including group A (model group), group B (group with 50％ magnesium sulfate for external application), group C (with Phentolamine for external application), group D (with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for external application) and group E (Phentolamine combined with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for external application). We compared the differences in naked eye observation, pathological observation and immunohistochemistry among five groups and compared the differences of group A with other four groups.Results There were no significant differences in effects of symptom observation among five groups on the first day after different treatments for amiodarone extravasation (P>0.05). The differences in treatment effects were significant among five groups on the second and third day after treatments (P<0.01). There were significant differences between group D and group A, group E and group A on the second and third day after treatments for extravasation (P<0.05). The differences in ear vein and surrounding tissues pathological injury of rabbits were significant among five groups on the third day after different treatments for amiodarone extravasation (P<0.05). There were significant differences in average positive rates of vascular endothelial growth factor (VEGF) among five groups (P<0.001), the average positive rate of VEGF in group A was higher than that in other four groups (P<0.05); the average positive rate of VEGF in group E was lower than that in other four groups with significant differences (P<0.05); there was no significant differences among group B, group C and group D (P>0.05).Conclusions The Phentolamine combined with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for phlebitis caused by amiodarone extravasation has obvious effects in an animal study.
