Treatment of Presumptive BK Nephropathy with Ciprofloxain in Kidney Transplant Recipients: Three Case Reports.
10.4285/jkstn.2014.28.4.254
- Author:
Hye Ran KANG
1
;
Seong Soon KWON
;
Seug Yun YOON
;
Eun Na KIM
;
Soon Hyo KWON
;
Jin Seok JEON
;
Hyunjin NOH
;
Dong Cheol HAN
;
So Young JIN
Author Information
1. Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. jeonjs@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
BK virus;
BK Nephropathy;
Kidney transplantation
- MeSH:
Allografts;
BK Virus;
Ciprofloxacin;
Glomerular Filtration Rate;
Humans;
Immunoglobulins;
Immunosuppression;
Kidney Transplantation;
Kidney*;
Transplantation*;
Viral Load;
Viremia
- From:The Journal of the Korean Society for Transplantation
2014;28(4):254-258
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BK virus nephropathy has emerged as an important cause of renal allograft dysfunction. Reduction in immunosuppression is the mainstay of BK virus nephropathy treatment. However, decreasing immunosuppressive medications is not sufficient for treatment of BK virus nephropathy. Therefore, there is a need for other treatment strategies such as cidofovir, leflunomide, and intravenous immunoglobulin in combination with immunosuppression reduction. Ciprofloxacin has recently been reported to have antiviral activity and decrease BK viral load in kidney transplant recipients. These findings suggest that the use of ciprofloxacin represents a valuable treatment strategy in patients with BK virus nephropathy. Here, we report on our experience with three patients who developed presumptive BK virus nephropathy after kidney transplantation, who, after 2 months of ciprofloxacin treatment, showed disappearance of BK viremia and improvement in the estimated glomerular filtration rate. Ciprofloxacin may be considered an effective treatment option for BK viremia in kidney transplant recipients.
