Research advances in healing mechanism of chronic refractory wounds mediated by long non-coding RNA
10.3760/cma.j.cn501120-20190526-00254
- VernacularTitle:长链非编码RNA介导慢性难愈性创面愈合的机制研究进展
- Author:
Peng WANG
1
;
Bin YIN
;
Yingjun SU
;
Chiyu JIA
Author Information
1. 厦门大学医学院 361102
- Keywords:
Wound healing;
Long non-coding RNA;
Chronic refractory wounds;
Mechanism
- From:
Chinese Journal of Burns
2020;36(8):758-761
- CountryChina
- Language:Chinese
-
Abstract:
Chronic refractory wound refers to the wound with unclear etiology, multiple and complex injury factors, slow healing, and no obvious tendency of healing after treatment for 4 weeks. The formation and evolution process of chronic refractory wounds are very complex, involving re-epithelialization of wound tissue, cell proliferation, tissue remodeling, and angiogenesis and lymphangiogenesis. The abnormal expression of long non-coding RNA may be involved in the formation of chronic refractory wounds, but the specific pathogenesis and related molecular biological changes are still controversial. In this paper, we reviewed the process and role of long non-coding RNA in regulating keratinocyte differentiation, fibroblast proliferation, and regeneration of vascular and lymphatic endothelial cell in chronic refractory wounds.
