Effects of octreotide on fecal characteristics and humoral immunity in neonates with necrotizing enterocolitis
- VernacularTitle:奥曲肽对新生儿坏死性小肠结肠炎患儿粪便性状及体液免疫的影响
- Author:
Jie ZHANG
1
;
Naiying MIAO
;
Huan LI
;
Xinjian LIU
Author Information
- Keywords: enterocolitis,necrotizing; infant,newborn; octreotide; immunity,humoral; fecal characteristics
- From: Tianjin Medical Journal 2024;52(12):1331-1334
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the effects of octreotide on fecal characteristics and humoral immunity in neonates with necrotizing enterocolitis(NEC).Methods A retrospective study was conducted on 60 newly born NEC patients at Hebei PetroChina Central Hospital from March 2022 to September 2023.The patients were separated into the observation group(30 cases)and the routine group(30 cases)based on treatment methods.The conventional group was treated with total parenteral nutrition and gastrointestinal decompression plus piperacillin sodium and tazobactam sodium for 7 days.The observation group was treated with octreotide in addition to the routine group for 5 days.The treatment efficacy,general clinical data,degree of intestinal microbiota disorder,expression levels of intestinal microbiota markers and immune indicators were compared between the two groups.Results The total effective rate of the observation group was higher than that of the routine group(P＜0.05).After treatment,body weight of the observation group was higher than that of the routine group.The hospitalization time,vomiting relief time,abdominal distension relief time,diarrhea relief time and complete recovery time of fecal characteristics were lower in the observation group than those in the routine group.Compared with before treatment,the degree of intestinal microbiota disorder and high mobility group box protein 1(HMGB1)were reduced in both groups after treatment,and expression levels of human β defensin 2(HBD2),autoinducer-2(AI-2)and serum immunoglobulin(Ig)A,IgG and IgM were increased(P＜0.05).After treatment,HMGB1 was lower in the observation group than that in the routine group,while HBD2,AI-2 and serum IgA,IgG and IgM were higher than those in the routine group(P＜0.05).Conclusion Octreotide can effectively treat children with NEC,improve stool characteristics,and enhance immunity.
