Research progress on the role of microglia polarization in neuropathic pain
- VernacularTitle:小胶质细胞极化在神经病理性疼痛中作用研究进展
- Author:
Jingjing CHEN
1
;
Zhangsong NONG
;
Liangyuan TAN
;
Peipei YANG
;
Yingye LIANG
;
Hongliang TANG
;
Kailong WANG
Author Information
- Keywords: microglia; inflammat ion; polarization; neuropathic pain
- From: Tianjin Medical Journal 2024;52(9):1000-1003
- CountryChina
- Language:Chinese
- Abstract: Neuropathic pain(NPP)is a recurrent and intractable pain syndrome,and microglial polarization is closely related to it.Recent studies have shown that after cell polarization,M1 pro-inflammatory and M2 anti-inflammatory types could be formed,and M1 and M2 microglial cells are involved in NPP through the modulation of inflammatory responses.The two types of microglial cells have different roles in NPP,just like a double-edged sword.M1 pro-inflammatory type plays an injurious role in NPP through the release of pro-inflammatory factors and noxious substances,whereas M2 anti-inflammatory type plays a protective role by secreting anti-inflammatory factors.In this article,the role of microglia polarization on NPP are reviewed.
