Examining the pathogenesis and therapeutic strategy of keloids from the perspective of systemic inflammation
10.3760/cma.j.cn501120-20200401-00205
- VernacularTitle:从全身性炎症角度审视瘢痕疙瘩发病机制和治疗策略
- Author:
Zhendong CAO
1
;
Wei LIU
Author Information
1. 上海交通大学医学院附属第九人民医院中医科 200011
- Keywords:
Keloid;
Traditional Chinese medicine;
Pro-inflammatory constitution;
Local and systemic interaction;
Systemic therapy
- From:
Chinese Journal of Burns
2020;36(5):334-338
- CountryChina
- Language:Chinese
-
Abstract:
Keloid is a disease that is difficult to cure and has a high recurrence rate. In the past, research on keloid focused on keloid cells themselves and the therapeutic strategy limited to local treatment, whereas the role of systemic factors in the process of occurrence and development of disease was usually neglected. Based on the literature reports and clinical evidence, we propose that the pro-inflammatory constitution of keloid patients can serve as a systemic factor to interact with local factors such as skin lesion, and thus leads to the initiation and development of keloid. The classical theory about close relationship between visceral malfunctions and skin diseases described in traditional Chinese medicine has provided supporting evidence. Therefore, we suggest that systemic anti-inflammatory therapy should be included in the design of future keloid therapeutic strategies and be verified by the clinical trials. Additionally, the therapeutic strategies of traditional Chinese medicine including anti-dampness, detoxing and heating removing can also be employed as a part of systemic treatment of keloids.
