Advances in the diagnostic and monitoring value of glycocalyx injury in inflammatory bowel disease
10.11958/20231646
- VernacularTitle:糖萼损伤对炎症性肠病的诊断和监测价值
- Author:
Ledan ZHANG
1
;
Mingxing JIN
;
Yandi LIU
Author Information
1. 南开大学医学院(邮编 300071)
- Keywords:
inflammatory bowel diseases;
intestinal mucosa;
syndecan-1;
heparitin sulfate;
hyaluronic acid;
glycocalyx damage
- From:
Tianjin Medical Journal
2024;52(8):893-896
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is no cure at present,and only drugs and surgery can relieve symptoms,delay and reduce recurrence.Therefore,it is very important to monitor the disease activity.Glycocalyx,a polyglycoprotein complex covering luminal side of vascular endothelial cells,is supportive in maintaining the intestinal mucosal barrier,and inflammation leads to its structural damage.This review introduces currently available non-invasive biomarkers of clinical importance for IBD in laboratory testing,and analyzes the value of serum glycocalyx injury markers(syndecan-1,HS and HA)in the diagnosis or monitoring of IBD.
