Research progress on the mechanism of the TGF-β signaling pathway in myelodysplastic syndrome
- VernacularTitle:TGF-β信号通路在骨髓增生异常综合征中作用机制的研究进展
- Author:
Qingqing LIU
1
;
Yiqiang LI
;
Yushi SHI
;
Haisong LU
;
Weimin CHENG
Author Information
- Keywords: myelodysplastic syndromes; transforming growth factor beta; signal transduction; immune cells; mechanism of action
- From: Tianjin Medical Journal 2024;52(7):781-784
- CountryChina
- Language:Chinese
- Abstract: Myelodysplastic syndrome(MDS)is a malignant clonal disease with high heterogeneity in cytogenetics and molecular genetics,and the risk of progression to acute myeloid leukemia(AML)is extremely high.Transforming growth factor-β(TGF-β)is closely related to the pathogenesis of MDS.It is a key executor of immune homeostasis and immune tolerance,and can inhibit the expansion and function of many components of immune system.TGF-β signaling pathway can regulate hematopoietic cells and immune cells in microenvironment,inhibit their normal biological functions,and thus accelerate the progression of MDS.This study reviews regulatory effects of TGF-β signaling pathway on MDS blood cells,T lymphocytes,natural killer cells and macrophages in recent years,and provides a new perspective for the pathogenesis and treatment of MDS.
