A prospective, randomized controlled clinical study on the optimal treatment interval of pulsed dye laser in treating hypertrophic scar after burn
10.3760/cma.j.cn501120-20200106-00008
- VernacularTitle:脉冲染料激光用于烧伤后增生性瘢痕的最佳治疗间隔的前瞻性随机对照临床研究
- Author:
Li YANG
;
Na LI
;
Jing CHENG
;
Juntao HAN
;
Dahai HU
- From:
Chinese Journal of Burns
2020;37(1):E022-E022
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the influence of different treatment intervals of pulsed dye laser (PDL) in treating hypertrophic scar of burn patients and to explore the optimal treatment interval.Methods:From May 2018 to March 2019 , 20 burn patients who met the inclusion criteria and admitted to the First Affiliated Hospital of Air Force Medical University were included in this prospective randomized controlled study. Patients were divided into 1 week group [4 patients, 2 males and 2 females, aged 27 (4, 67) years,19 scars], 2 weeks group [5 patients, 2 males and 3 females, aged 9 (3, 55) years, 15 scars], 3 weeks group [5 patients, 4 males and 1 female, aged 26 (19, 45) years,15 scars], and 4 weeks group [6 patients, 4 males and 2 females, aged 31 (14, 48) years,13 scars], according to the random number table, and treated with PDL with the treatment intervals of one week, two weeks, three weeks, and four weeks, respectively, and total treatment cycle of 3 months. Before the first treatment and three months after the first treatment, the Vancouver Scar Scale (VSS) was conducted and the decreased value of VSS score was calculated; the laser doppler blood flow meter was used to measure scar blood perfusion and the proportion of change in blood perfusion volume was conducted. Data were statistically analyzed with Kruskal-Wallis test, Wilcoxon rank sum test, Wilcoxon symbolic rank sum test, Bonferroni correction, and Fisher’s exact probability test.Results:The VSS scores of patients in 1 week group, 2 weeks group, 3 weeks group, and 4 weeks group in three months after the first treatment were significantly lower than those before the first treatment ( Z=-3.74, -3.47, -2.69, -3.25, P<0.01). There were no statistically significant differences in the decreased values of VSS scores in three months after the first treatment among the patients in 4 groups ( H=5.18, P>0.05). Three months after the first treatment, the blood perfusion volumes of patients in 2 weeks group and 3 weeks group were significantly lower than those before the first treatment ( Z=-2.95, -2.50, P<0.05). The proportions of changes in blood perfusion volume of patients in the 4 groups were respectively -0.02(-1.05-0.69), -0.29 (-0.75-0.18), -0.11 (-0.55-0.23), 0.05 (-0.61-0.75). There were statistically significant differences among the 4 groups ( H=9.39, P<0.05). The proportions of changes in blood perfusion volume of patients in 2 weeks group was statistically higher than that of 1 week group ( Z=2.76, P<0.01). Conclusions:PDL treatment can reduce the VSS score and blood perfusion volume of scar, the blood perfusion volumes of patients in 2 weeks group and 3 weeks group were significantly decreased, they can be recommended as the appropriate treatment interval of PDL for hypertrophic scar after burn.
