Research progress of dermatomyositis-related autoantibodies in interstitial lung disease
- VernacularTitle:皮肌炎自身抗体在间质性肺病中的研究进展
- Author:
Yanran LUO
1
,
2
;
Xiaofei SHI
;
Lei HAN
;
Bei ZHANG
;
Luyao WEN
Author Information
- Keywords: dermatomyositis; interstitial lung disease; antoantibody; clinical features; prognosis
- From: Tianjin Medical Journal 2024;52(7):704-708
- CountryChina
- Language:Chinese
- Abstract: Myositis antibodies are divided into myositis-specific autoantibodies(MSA)and myositis-associated autoantibodies(MAA).There are heterogeneity in the mechanism,clinical features and prognosis of interstitial lung disease(ILD)in the different myositis antibodies.In MSA,anti-melanoma differentiation-related gene 5(MDA5)antibody and anti-aminoacyl synthetase(ARS)antibody are highly correlated with the occurrence of ILD.Patients with MDA5+DM-ILD usually have a rapidly progressive and poor prognosis.The progress of ILD in ARS+DM patients was slow,and the response to treatment is good,but it is easy to relapse.In MAA,anti-Ro52 antibodies often coexist with MSA antibodies,and clinical manifestation is closely related to coexisting antibodies.This review has summarized roles of myositis antibodies in ILD.
