Predictive value of systemic immune inflammation index(SII)on long-term survival of patients with stage Ⅲ squamous lung cancer treated with radical radiotherapy
- VernacularTitle:系统免疫炎症指数对根治性放疗Ⅲ期肺鳞癌患者长期生存的预测价值
- Author:
Jingchen HUO
1
;
Yue WANG
;
Hua LI
;
Rong QIU
;
Jingwei SU
;
Zhuofan WANG
;
Jie YANG
Author Information
- Keywords: lung neoplasms; carcinoma,non-small-cell lung; survival rate; progression-free survival; stage Ⅲ lung squamous cell cancer; radiotherapy; systemic immune-inflammation index
- From: Tianjin Medical Journal 2024;52(6):634-638
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the predictive value of systemic immune inflammation index(SII)scores in long-term survival of patients with stage Ⅲ squamous lung cancer treated with radical radiotherapy.Methods Clinical data of stage Ⅲ squamous lung cancer patients who underwent radical radiotherapy at the Radiotherapy Department of the Fourth Hospital of Hebei Medical University from January 2010 to December 2018 were retrospectively analyzed.The peripheral hematological indexes one week before radiotherapy were collected and recorded.X-Tile software was applied to determine the best cut-off values for continuous variables.Kaplan-Meier method was used to analyze overall survival(OS)and progression-free survival(PFS).Results A total of 453 patients were included in this study.There were 336 patients in the low SII group(＜1 277.3),and other 117 patients were in the high SII group(≥1 277.3).The median OS and median PFS in the high SII group were shorter than those in the low SII group(OS:20.8 months vs.31.0 months,Log-rank χ2=18.015,P＜0.01;PFS:13.0 months vs.21.0 months,Log-rank χ2=15.062,P＜0.01).Multivariate Cox regression analysis showed that high SII was associated with OS(HR=1.628,95%CI:1.294-2.047,P<0.001)and PFS(HR=1.559,95%CI:1.240-1.961,P<0.001).Other influencing factors included late TNM stage,poor radiotherapy efficacy and decreased HALP score.Conclusion SII can be used to evaluate the long-term survival of patients with stage Ⅲ lung squamous cell carcinoma receiving radical radiotherapy,and the increase of SII indicates a poor prognosis.
