Precision evaluation of immune status and its significance in sepsis after burns or trauma
10.3760/cma.j.issn.1009-2587.2018.11.013
- VernacularTitle:烧创伤脓毒症免疫状态精准评估及其价值
- Author:
Yongming YAO
1
;
Yingyi LUAN
Author Information
1. 解放军总医院第一附属医院创伤研究中心
- Keywords:
Burns;
Sepsis;
Immunity;
Monitoring
- From:
Chinese Journal of Burns
2018;34(11):786-789
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis induced by major burns,trauma,and hemorrhage,remains a major cause of death of patients in intensive care units,and it may result in both the widespread activation and dysfunction of the innate as well as adaptive responses in host immune system.A large amount of information concerning subsets of innate and adaptive immune cells in sepsis has implicated that these cells,including neutrophils,macrophages,dendritic cells,T lymphocytes,regulatory T lymphocytes,and natural killer cells,have profound effects on immunoreactivity during acute insults or sepsis through modulating multiple receptor expressions or cytokine secretion,in turn contributing to the development and outcome of sepsis.It is of great significance that precision monitoring of immune function and the related indicators might help to assess the risk of secondary infection,the prognosis of septic patients,and guide the treatment of septic complications.
