Long non-coding RNA and wound healing
10.3760/cma.j.issn.1009-2587.2016.12.008
- VernacularTitle:长链非编码核糖核酸与创面愈合
- Author:
Yang LIU
1
;
Dewu LIU
Author Information
1. 330006,南昌大学第一附属医院烧伤科
- Keywords:
Wound healing;
Cicatrix;
Wound reepithelialization;
Angiogenesis;
Long non-coding RNA
- From:
Chinese Journal of Burns
2016;32(12):735-739
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA (lncRNA) is a class of RNA molecules longer than 200 nucleotides which does not encode proteins or only encode a few proteins,and it plays important regulatory roles in the expression of genes at the epigenetie,transcriptional,and posttranscriptional levels.The recent reports suggest that lncRNA plays a significant role in growth and development of body,cellular biological processes including in cell proliferation,differentiation,migration,and apoptosis,and regulation of wound healing processes such as re-epithelialization,angiogenesis,and scar formation.The lncRNA has become a new research hotspot in wound healing.This article reviews the role of lncRNA in different stages of wound repair to get a further understanding of molecular mechanisms of wound healing and provide a new target spot for prevention and treatment of pathological scars and wound healing.
