Research Progress on the Interaction Mechanism Between Nociceptors and Immunity in Pain
10.3870/j.issn.1672-0741.24.04.004
- VernacularTitle:伤害性感受器与免疫系统在疼痛中交互作用及机制的研究进展
- Author:
Yali LI
1
;
Shaomeng SI
;
Fanglong HAN
Author Information
1. 华中科技大学同济医学院附属同济医院麻醉学与疼痛医学科,老年麻醉与围术期脑健康湖北省重点实验室,武汉市老年麻醉临床医学研究中心,武汉 430030
- Keywords:
nociceptors;
immunity;
pain;
inflammation
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(5):687-692
- CountryChina
- Language:Chinese
-
Abstract:
Nociceptive sensory neurons are widely distributed throughout various parts of the body to detect harmful stimu-li and transmit pain sensations.In recent years,the interactions between nociceptive sensory neurons and the immune system have garnered increasing attention from researchers.Immune cells and inflammatory factors promote the activation of nocicep-tors and the transmission of pain;conversely,nociceptors also participate in regulating the body's immune functions.The bal-ance between these two systems is beneficial for self-protection under harmful stimuli and infection.Moreover,this neuroim-mune interaction may underlie the coexistence and mutual promotion of hyperalgesia and inflammation.This review primarily discusses the role of interactions between nociceptors in various body regions and the immune system in pain,as well as the po-tential molecular mechanisms involved.This study aims to provide insights and theoretical foundations for developing new strat-egies for pain management.
