Mechanisms of Axonal Transport Deficits in Neurodegenerative Diseases
10.3870/j.issn.1672-0741.23.01.008
- VernacularTitle:神经退行性疾病中轴突运输障碍的机制
- Author:
Xiaoman YANG
1
,
2
;
Yan XU
;
Xuebing CAO
Author Information
1. 武汉大学人民医院神经内科,武汉 430060
2. 华中科技大学同济医学院附属协和医院神经内科,武汉 430022
- Keywords:
axonal transport deficit;
Alzheimer's disease;
amyotrophic lateral sclerosis;
Parkinson's disease
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(4):558-562
- CountryChina
- Language:Chinese
-
Abstract:
Numerous neurodegenerative diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,exhibit a common pathophysiological hallmark of aberrant protein aggregation and organelle mislocalization.These pathological manifestations are hypothesized to stem from disruptions in axonal transport within neurons,resulting in the im-paired targeting of pathological proteins for degradation and the misplacement of organelles crucial for normal cellular func-tions.This review aims to illustrate the mechanisms responsible for axonal transport deficits in various prevalent neurodegenera-tive diseases,suggesting that these deficits are typically early pathological occurrences that ultimately result in the deterioration of axonal integrity and degenerative alterations.The review may offer novel insights for future fundamental research endeavors.
