Research Progress on Histones Modification Regulating the Pathogenesis in Acute Myocardial Infarction
10.3870/j.issn.1672-0741.23.12.007
- VernacularTitle:组蛋白修饰调控急性心肌梗死发病机制的研究进展
- Author:
Caiying HU
1
;
Bin WEN
Author Information
1. 武汉市红十字会医院心内科,武汉 430015
- Keywords:
acute myocardial infarction;
epigenetic;
histone modification
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(4):535-538,568
- CountryChina
- Language:Chinese
-
Abstract:
Histone modification plays an important role in the occurrence and development of acute myocardial infarction(AMI).When AMI occurs,due to the lack of energy supply,the main energy-supplying organelle of cardiomyocytes,mitochon-dria,cannot synthesize ATP normally,which leads to mitochondrial dysfunction,which can induce the apoptosis of cardiomyo-cytes.In addition,apoptosis also plays an important role.Histone modification includes methylation,acetylation,phosphoryla-tion,lactylation and other mechanisms.These diverse modifications cooperate and antagonize each other in the occurrence and development of myocardial infarction,forming a complex regulatory network.Histone modification can alleviate the apoptosis and focal death induced by inflammation by regulating the expression of related genes,thus affecting the pathogenesis of AMI.In this paper,the research progress of histone modification in the pathogenesis of acute myocardial infarction was re-viewed.
