Research Progress of Ubiquitination in Ferroptosis Pathway
10.3870/j.issn.1672-0741.24.04.001
- VernacularTitle:铁死亡通路泛素化调控的研究进展
- Author:
Wenjia WANG
1
;
Qilong XIA
;
Di ZHANG
Author Information
1. 华中科技大学同济医学院附属同济医院中西医结合研究所,武汉 430030
- Keywords:
ferroptosis;
ubiquitination;
E3 ubiquitin ligase;
deubiquitinase
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(4):528-534
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is closely associated with the progression of various diseases.There are a series of anti-ferroptosis systems in the cell,the main function of which is to eliminate lipid peroxides and inhibit the occurrence of ferropto-sis.Ubiquitination is a crucial type of post-translational protein modification which can influence the degradation,intracellular localization,or function of substrate proteins.Ubiquitination modification plays an important role in regulating key proteins in-volved in ferroptosis pathways,such as SLC7A11,GPX4,FSP1,iron metabolism-related proteins,and other critical proteins in ferroptosis pathways.This review aims to summarize the research progress on ubiquitination modification of these key proteins in ferroptosis pathways,thereby elucidating the specific role of ubiquitination in ferroptosis pathways.
