Causal Relationship Between Circulating Immune Cells and the Risk of Coronary Heart Disease:A Bidirectional Mendelian Randomization Based Study
10.3870/j.issn.1672-0741.24.03.002
- VernacularTitle:基于双向孟德尔随机化研究循环免疫细胞与冠心病风险之间的因果关系
- Author:
Yinfei LU
1
,
2
;
Long LI
;
Xia ZHAO
Author Information
1. 石河子大学第一附属医院心内科,石河子 832000
2. 国家卫生健康委员会中亚高发病防治重点实验室,石河子 832000
- Keywords:
mendelian randomization;
immune cell;
coronary heart disease;
atherosclerosis;
causality
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(4):487-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective The immune response plays a crucial role in the progression of coronary heart disease(CHD).But the specific immune cells that may be causally related to CHD are still not fully understood.This study aimed to investigate the po-tential causal relationship between immune cells and CHD by using Mendelian randomization(MR)studies.Methods This study utilized publicly available Genome Wide Association Study(GW AS)data to analyze 731 immune traits in relation to CHD through MR analysis.The primary analytical method employed was the inverse variance weighting method to evaluate effects,with additional methods employed to corroborate the findings.Sensitivity analyses,including horizontal pleiotropy test,heteroge-neity test,and leave-one-out methods were also carried out.Results Following Bonferroni correction,a significant correlation was found between B cell absolute count(OR=1.064,95％CI:1.032-1.096,P＜0.01)and an increased risk of CHD.Sensitivity analysis was performed to confirm the reliability of these results.The inverse MR analysis suggested that there was no causal relationship between CHD and immune cells.Although other immune cell traits did not show a significant impact on CHD,they did exhibit low unadjusted P values.Conclusion This study highlighted the strong association between B cells and CHD at a genomic level,providing valuable insights for future clinical diagnosis and treatment.
