The effect of continuous Jue tone intervention on blood pressure and vasoactive substances in hypertensive rats with a liver-fire hyperactivity pattern
- Author:
Zhou QIAN
1
,
2
;
Chen YUFENG
;
Zhang SITONG
;
Yang PEI
;
Wang TIAN
;
Chen JIANXIN
;
Zhao HUIHUI
;
Wang WEI
;
Ma XUELING
Author Information
1. School of Nursing,Beijing University of Chinese Medicine,Beijing 102488,China
2. School of Nursing and Health,Zhengzhou University,Zhengzhou 450000,China
- Keywords:
Hypertension;
Music therapy;
Reactive oxygen species;
Mechanism;
Vasoactive substances;
Chinese five-tone;
Traditional Chinese medicine;
Non-drug therapy
- From:
Journal of Traditional Chinese Medical Sciences
2022;9(1):40-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Jue tone is a kind of sound,using 3-mi as the main tone,and is melodious,profound,makes people feel comfortable and pleasant.This study aimed to explore the probable mechanism of Jue tone to reduce blood pressure (BP) in hypertensive rats with a liver-fire hyperactivity pattern by observing changes in BP as well as physiochemical indexes in plasma.Methods:Sixteen male spontaneous hypertensive rats (SHR) with a liver-fire hyperactivity pattern were randomly divided into a control group and a Jue tone group.The rats in the Jue tone group were treated with Jue tone (55-65 dB,played by the five elements of music rhythm instrument,a kind of physio-therapy regimen music played by Shen Wu) once a day for 4 weeks.The BP levels in each group were measured twice a week,on Monday and Friday.The levels of angiotensin Ⅱ (Ang-Ⅱ),thromboxane B2(TXB2),endothelin-1 (ET-1),calcitonin gene-related peptide (cGRP),norepinephrine (NE),cortisol(CORT),and 5-hydroxytryptamine (5-HT).in plasma were detected by enzyme-linked immunosorbent assay after 4 weeks of intervention.Results:BP and the levels of TXB2 and ET-1 in the plasma of the treatment group were significantly lower than those of the control group,while the level of cGRP was significantly higher.Conclusion:Jue tone can reduce the BP of hypertensive rats with a liver-fire hyperactivity pattern.The mechanism may correlate with a reduction in TXB2 and ET-1 and an increase in cGRP with the reduction of reactive oxygen species (ROS).
