The role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease
- Author:
Chen ZHENJIE
1
;
Yuan KAI
;
Yan RUNZE
;
Yang HANWEN
;
Wang XIAONA
;
Wang YI
;
Wei SHUWU
;
Huang WEIJUN
;
Sun WEIWEI
Author Information
1. Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,100700,China
- Keywords:
Diabetic kidney disease;
Endothelial dysfunction;
Endothelial inflammation;
Damp-heat syndrome;
Internal heat-induced hump accumulation;
Serum biomarker;
24 h urine Protein;
Estimated glomerular filtration rate
- From:
Journal of Traditional Chinese Medical Sciences
2022;9(1):34-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease (DKD).Methods:A total of 183 patients with DKD were divided into 3 groups:the early DKD group,established DKD group,and advanced DKD group.All patients were classified according to traditional Chinese medicine (TCM) syndrome type,and clinical indexes were collected for statistical analysis.Results:A total of 183 DKD patients were included in this study.Fibroblast growth factor 23 (FGF23),chitinase-3-like protein 1 (CHI3L1),endocan,tumor necrosis factor receptor 1 (TNFR1),secretory leukocyte protease inhibitor (SLPI),and vascular endothelial growth factor A (VEGF-A) were increased in advanced DKD.FGF23,CHI3L1,endocan,SLPI,and TNFR1 showed a negative correlation with estimated glomerular filtration rate (eGFR),while they had a positive correlation with 24 h urine protein.After adjusting for age,gender,diabetes duration,body mass index (BMI),hemoglobin,glucose,uric acid,24 h urine protein,cholesterol,triglyceride,low-density lipoprotein,and hemoglobin A1c (HbA1c),the multiple regression analysis showed that FGF23,endocan,TNFR1,and SLPI significantly correlated with eGFR.Conclusions:FGF23,endocan,TNFR1,and SLPI are elevated in advanced DKD compared with early stage,and they may take part in the pathogenesis and progression of DKD.Our study provides useful bio-markers for predicting the appearance of damp-heat syndrome,including FGF23,endocan,TNFR1,and SLPI.
