Role of metabolic reprogramming-mediated hepatic stellate cell activation in the pathogenesis of hepatic fibrosis
10.3760/cma.j.cn501113-20240223-00088
- VernacularTitle:代谢重编程介导的肝星状细胞活化在肝纤维化发生机制中的作用
- Author:
Ying XIAO
1
;
Zhinian WU
;
Jie LU
;
Yadong WANG
Author Information
1. 河北医科大学第三医院感染科，石家庄 050051
- Keywords:
Hepatic fibrosis;
Hepatic stellate cell;
Metabonomics;
Energy metabolism;
Metabolic reprogramming
- From:
Chinese Journal of Hepatology
2024;32(11):1053-1056
- CountryChina
- Language:Chinese
-
Abstract:
The activation of hepatic stellate cells (HSCs) and excessive deposition of extracellular matrix are the keys to the occurrence and development of liver fibrosis. Metabolic reprogramming supports the activation process of HSCs, which requires substantial energy to meet the corresponding energy requirements for liver fibrosis formation. This review focuses on the effect of metabolomic changes characterized by metabolic reprogramming on HSC activation and summarizes the characteristics of HSC energy metabolism reprogramming during the formation of liver fibrosis, with the aim to summarize research evidence for exploring the mechanism and developing strategies for the prevention and treatment of liver fibrosis.
