HBsAg trajectory and key watersheds towards functional cure of hepatitis B

VernacularTitle:走向乙型肝炎功能性治愈的HBsAg轨迹及关键分水岭
Author: Xieer LIANG ¹ ; Zhihong LIU ; Yongyin LI ; Rong FAN ; Jinlin HOU
Author Information

1. 南方医科大学南方医院感染内科，广州　510515
Keywords: Hepatitis B; Functional cure; Hepatitis B surface antigen; Therapy
From: Chinese Journal of Hepatology 2024;32(11):961-964
CountryChina
Language:Chinese
Abstract: Chronic hepatitis B virus (HBV) infection remains a pivotal global public health concern. Attaining a functional cure for hepatitis B continues to be a hot and difficult issue that requires immediate attention in clinical practice. There are currently nucleos(t)ide analogues (NAs) that can persistently suppress HBV DNA; however, the functional cure rate of pegylated interferon alfa (PEG-IFN-α) alone or in combination with NAs has not yet met clinical needs. The research and development on novel mechanisms for HBV antiviral drugs, especially small nucleic acid drugs, has brought breakthroughs to the functional cure of hepatitis B. The functional cure trajectory mapping and its prediction model can guide the selection of clinical treatment strategies based on the longitudinal data for HBsAg at various time intervals. The personalized management of hepatitis B patients can be optimized by utilizing varying HBsAg levels as a key watershed to aid in the screening of subjects in clinical trials.