Preventive effect of nasal Timosaponin BⅡ-loaded temperature-/ion-sensitive in situ hydrogels on Alzheimer's disease
- Author:
Ou GE
1
,
2
;
Chen WENYUAN
;
Yang MEIYAN
;
Li QIAN
;
Zhang YUANYUAN
;
Wan DELIAN
;
Du LINA
;
Ma BAIPING
Author Information
1. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China
2. Pharmacy Department, Chinese PLA General Hospital, Beijing 100853, China
- Keywords:
Timosaponin BⅡ;
Alzheimer's disease;
In situ hydrogels;
Intranasal administration
- From:
Journal of Traditional Chinese Medical Sciences
2021;8(1):59-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the preventive effect of Timosaponin BⅡ (T-BⅡ) -loaded temperature/ion-sensitive nasal in situ hydrogels (ISGs) on Alzheimer's disease (AD), its preparation technology, characteristics and in vivo effects were evaluated.Methods: The morphological and rheological properties were evaluated. The preventive effects of T-BⅡ ISG on scopolamine-induced AD in mice were determined with the index of muscarinicreceptor 1 (M1) expression and pathological changes. Results: Results revealed that T-BⅡ ISG significantly increased the content of M1 choline receptors in the hippocampus of mice and ameliorated the damage incurred to the hippocampal cornu ammonis 1 (CA1) area. Conclusion: T-BⅡ ISGs is a reasonable and convenient method of exerting an obvious preventive effect on mice with AD induced by scopolamine. This, thereby, lays forth a new treatment option for preventing AD.
