Immunohistochemical Expression of CXC Chemokine Receptor 4 and Galectin-3 in Follicular Tumors of Thyroid.
10.11106/jkta.2012.5.1.45
- Author:
Ji Eun PARK
1
;
Bu Kyung KIM
;
Sangeon GWOO
;
Yo Han PARK
;
Young Sik CHOI
;
Young Ok KIM
Author Information
1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. yschoi@Kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
Follicular tumor;
Galectin-3;
CXCR4
- MeSH:
Adenoma;
Carcinoma, Papillary;
Diagnosis, Differential;
Galectin 3;
Paraffin;
Receptors, CXCR;
Receptors, CXCR4;
Sensitivity and Specificity;
Thyroid Gland
- From:Journal of Korean Thyroid Association
2012;5(1):45-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Follicular tumors can present a difficult diagnostic challenge for cytological evaluation and ultrasound findings. Therefore, new methods which could help distinguish follicular adenoma from follicular carcinoma simply and accurately are greatly desired. This study investigated the usefulness of immnunohistochemical expression of CXC chemokine receptor 4 (CXCR4) and galectin-3 as marker of differentiated thyroid carcinomas. MATERIALS AND METHODS: Expression of CXCR4 and galectin-3 were examined immunohistochemically in the 60 paraffin embedded tissues which were already diagnosed as follicular adenoma (n=20), follicullar carcinoma (n=20), and papillary carcinoma (n=20) of thyroid. RESULTS: Galatin-3 was expressed significantly high in follicular carcinoma than follicular adenoma (p=0.022). CXCR4 was also expressed significantly high in follicular carcinoma than follicular adenoma (p=0.027). The sensitivity of CXCR4 and galectin-3 was 70% and 80% and specificity, 65% and 60% for differential diagnosis of follicular tumors. CONCLUSION: An immunohistochemical panel, including galatin-3 and CXCR4, could be useful in the differential diagnosis between follicular adenoma from follicular carcinoma.
